I Heineken Grande Prêmio do São Paulo
| Date | Sunday 14 November 2021 |
| Start time | 14:00 |
| Event | São Paulo GP |
| Circuit | Interlagos |
| Event Format | Sprint race of 24 laps, followed by a race of 71 laps |
| Championship | World Championship |
| Race number | #19 of 22 in 2021 #1054 (of all time) |
| Laps | 71 |
| Circuit Perimeter | 4309 m |
| Race Distance | 4309 × 71 − 60 = 305.879 km |
| Grid Format | 2-2-2-2 (staggered) |
| Pole Position | Right |
| First Corner | Left |
| Track Direction | Anti-clockwise |
| Entries | 20 |
| Qualifiers | 20 |
| Finishers | 18 |
| Pit stops | 79 |
| Debutants | São Paulo GP (Event) |
| Records Broken |
None
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| Records Extended |
1. Most Constructors' Championship Points Scores – Ferrari (1198),
2. Most Drivers' Championship Points Scores – Ferrari (1330),
3. Most Podium Finishes – Lewis Hamilton (179),
4. Most Constructors' Championship Points Scores – Lewis Hamilton (231),
5. Most Drivers' Championship Points Scores – Lewis Hamilton (246),
6. Most Race Wins – Lewis Hamilton (101),
7. Most 5th Place Finishes – Ferrari (143),
8. Most 6th Place Finishes – Ferrari (124),
9. Most 16th Place Finishes – Williams (47),
10. Highest Race Win Ratio – Mercedes (24.06%),
11. Most Races Led – Lewis Hamilton (174),
12. Most Laps Led – Lewis Hamilton (5272),
13. Most Race Entries – Ferrari (2274),
14. Most Race Entries – Kimi Räikkönen (349),
15. Most 5th Place Qualifications – Ferrari (240),
16. Most 6th Place Qualifications – Ferrari (201),
17. Most 17th Place Qualifications – Williams (61),
18. Most 9th Place Qualifications in a Season – Fernando Alonso (7)
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| | Recipient | Trophy Presented By |
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| Winner | Lewis Hamilton | João Doria | Governor of São Paulo |
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| 2nd Place | Max Verstappen | Ricardo Nubes | Mayor of São Paulo |
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| 3rd Place | Valtteri Bottas | Giovanni Guerra | ASN President |
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| Winning Constructor | Mercedes (represented by Leonardo Donisete da Silva) | Mauricio Giamellaro | President, Heineken Brazil |
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